PEOPLE


 

Lab Member Profile


Name Goes Here

David Tsai
NHMRC CJ Martin Biomedical Fellow

Ph.D., Biomedical Engineering, University of New South Wales, 2012
M. BiomedE., University of New South Wales, 2007
B.E. (Hons 1st class), University of New South Wales, 2007

dtsai AT ee DOT columbia DOT edu

Link to CV

Research Summary

I work at the junction between engineering and neuroscience. My present research include:

  1. CMOS multielectrode array technologies and analytical systems for large-scale, simultaneous recording and stimulation of neuronal population.
  2. Understanding the computational principles of the retina, through a combination of research tools: electrophysiology, imaging, and computational simulation.
More about me

Journals

  • K Jayant, J Hirtz, I J Plante, D Tsai, W De Boer, A Semonche, D Peterka, J Owen, O Sahin, K Shepard, R Yuste, Targeted intracellular voltage recordings from dendritic spines using quantum-dot coated nanopipettes, Nature Nanotechnology, 2016 (accepted) [pubmed].
  • T Guo, D Tsai, J W Morley, G J Suaning, T Kameneva, N H Lovell, S Dokos, Electrical Activity of ON and OFF Retinal Ganglion Cells: A Modelling Study, Journal of Neural Engineering, 2016(13) 025005, [pubmed].
  • J Choi, E Aklimi, C Shi, D Tsai, H Krishnaswamy, K L Shepard, Matching the power, voltage, and size of biological systems: a nW-scale, 0.023-mm3 pulsed 33-GHz radio transmitter operating from a 5kT/q-supply voltage, IEEE Transactions on Circuits and Systems, 2015(62) 1950–1958, [IEEE Explore].
  • T Gou, D Tsai, J W Morley, G J Suaning, N H Lovell, S Dokos, Understanding the retina: a review of computational models of the retina from the single-cell to network level, Critical Reviews in Biomedical Engineering, 2014(42) 419-436 [pubmed].
  • P B Matteucci, S C Chen, D Tsai, C W Dodds, S Dokos, J W Morley, N H Lovell, G J Suaning, Current steering in retinal stimulation via a quasimonopolar stimulation paradigm, Investigative Ophthalmology & Visual Science , 2013(54) 4307-4320, [pubmed].
  • D Tsai, S C Chen, D A Protti, J W Morley, G J Suaning, N H Lovell, Responses of retinal ganglion cells to extracellular electrical stimulation from single cell to population: model-based analysis, PLoS ONE, 2012(7) e53357. [pubmed].
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Frequency–dependent reduction of voltage-gated sodium channels modulates retinal ganglion cell response rate to electrical stimulation, Journal of Neural Engineering, 2011(8) 066007, (featured article). [pubmed].
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Direct Activation and Temporal Response Properties of Rabbit Retinal Ganglion Cells Following Subretinal Stimulation, Journal of Neurophysiology, 2009(102) 2982–2993 (cover article). [pubmed].
  • D Tsai, J W Morley, G J Suaning, N H Lovell, A wearable real–time image processor for a vision prosthesis, Computer Methods and Programs in Biomedicine, 2009(95) 258–269. [pubmed].

Peer reviewed proceedings

  • T Guo, A Barriga-Rivera, G Suaning, D Tsai, S Dokos, J W Morley, N H. Lovell, Mimicking natural neural encoding through retinal electrostimulation, Proceedings of the 8th International IEEE EMBS Conference on Neural Engineering, 2017 (4 pages, accepted).
  • C-Y Yang, D Tsai, T Guo, G Suaning, S Dokos, J W Morley, N H Lovell, High Frequency Electrical Stimulation: the Effect of Spatial Location on Retinal Ganglion Cell Responses In Vitro, Proceedings of the 38th Annual International Conference of the IEEE EMBS, 2016 (4 pages, accepted).
  • D Tsai, E John, T Chari, R Yuste, K L Shepard, High-channel-count, high-density microelectrode array for closed-loop investigation of neuronal networks, Proceedings of the 37th Annual International Conference of the IEEE EMBS, 2015 (4 pages). (Best 10 papers, with JBHI invitation).
  • C Yang, A Woolley, D Tsai, G J Suaning, J W Morley, N H Lovell, Calcium imaging of retinal ganglion cell dendritic responses to extracellular microelectrode stimulation, Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, 2015 (4 pages).
  • T Guo, N H Lovell, D Tsai, P Twyford, S Fried, J W Morley, G J Suanning, S Dokos, Optimizing retinal ganglion cell responses to high-frequency electrical stimulation strategies for preferential neuronal excitation, Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, 2015 (4 pages).
  • S Bai, T Guo, D Tsai, J W Morley, G J, Suanning, N H Lovell, S Dokos, Influence of retinal ganglion cell morphology on neuronal response properties: a simulation study, Proceedings of the 7th International IEEE EMBS Conference on Neural Engineering, 2015 (4 pages).
  • J Choi, E Aklimi, J Roseman, D Tsai, H Krishnaswamy, K L Shepard, Matching the power density and potentials of biological systems: a 3.1-nW, 130-mV, 0.023-mm3 pulsed 33-GHz radio transmitter in 32-nm SOI CMOS, Proceedings of the IEEE Custom Integrated Circuits Conference, 2014.
  • T Gou, N H Lovell, D Tsai, P. Twyford, S. Fried, J W Morley, G J Suaning, S Dokos, Selective activation of ON and OFF retinal ganglion cells to high-frequency electrical stimulation: A computational modeling study, Proceedings of the 36th Annual International Conference of the IEEE EMBS, 2014 (4 pages). (Student paper competition Asia-Pacific finalist).
  • T Guo, D Tsai, J W Morley, G J Suaning, N H Lovell, S Dokos, Cell-specific modeling of retinal ganglion cell electrical activity, Proceedings of the 35th Annual International Conference of the IEEE EMBS, 2013 accepted (4 pages) (Student paper competition finalist).
  • T Guo, D Tsai, S. Sovilj, J W Morley, G J Suaning, N H Lovell, S Dokos, Influence of active dendrites on firing patterns in a retinal ganglion cell model, Proceedings of the 35th Annual International Conference of the IEEE EMBS, 2013 accepted (4 pages).
  • T Guo, D Tsai, J W Morley, G J Suaning, N H Lovell, S Dokos, Influence of cell morphology in a computational model of ON and OFF retinal ganglion cells, Proceedings of the 35th Annual International Conference of the IEEE EMBS, 2013 accepted (4 pages).
  • T Guo, D Tsai, N H Lovell, S Dokos, Modeling Normal and Rebound excitation in Mammalian Retinal Ganglion Cells, Proceedings of the 34th Annual International Conference of the IEEE EMBS, 2012 (4 pages).
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Responses of starburst amacrine cells to prosthetic stimulation of the retina, Proceedings of the 33rd Annual International Conference of the IEEE EMBS, 2011 (4 pages).
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Sodium channel inactivation reduces retinal ganglion cell responsiveness to repetitive prosthetic stimulation, The 5th international IEEE EMBS Conference on Neural Engineering, 2011 (4 pages).
  • G J Suaning, S Kisban, S C Chen, P J Byrnes-Preston, C Dodds, D Tsai, P Matteucci, S Herwik, J W Morley, N H Lovell, O Paul, T Stieglitz, P Ruther, Discrete Cortical Responses from Multi–site Supra–Choroidal Electrical Stimulation in the Feline Retina, Proceedings of the 32nd Annual International Conference of the IEEE EMBS, Buenos Aires, 2010 (4 pages).
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Direct Activation of Retinal Ganglion Cells with Subretinal Stimulation, Proceedings of the 31st Annual International Conference of the IEEE EMBS, 2009 (4 pages).

Conferences

  • D Tsai, Ken Shepard, CMOS Neuroprobes, Materials Research Society (MRS) Spring Meeting 2017, Phoenix Arizona, Apr. 2017.
  • J W Morley, C-Y Yang, D Tsai, T Guo, G Suaning, S Dokos, N H Lovell, High Frequency Electrical Stimulation: the Effect of Spatial Location on Retinal Ganglion Cell Responses In Vitro, Neuroscience 2016, San Diego CA, USA, 2016.
  • K Jayant, J J Hirtz, I J-L Plante, D T Tsai, W D Boer, A Semonche, D Peterka, J S Owen, O Sahin, K L Shepard, R Yuste, Direct electrical recordings from dendritic spines using nano-pipettes, Neuroscience 2015, Chicago IL, USA, 2015.
  • D Tsai, E John, R Yuste, K L Shepard, Advancing the state-of-the-art in electrophysiology: pushing the limits on amplifier density, IEEE EMBS BRAIN Grand Challenges Conference, Washington DC, USA, 2014.
  • T Guo, D Tsai, G J Suaning, N H Lovell S Dokos, Influence of dendritic structure on retinal ganglion cell firing pattern: a modeling study, NeuroEng 2013: 6th Australian Workshop on Computational Neuroscience, Melbourne, Australia (NeuroEng student prize).
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Temporal response profiles of amacrine cells following electrical stimulation of the retina, Neuroscience 2011, Washington DC, USA, 2011.
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Activation of voltage-gated ion channels in rabbit retinal ganglion cells following electrical stimulation of the retina, Australian Neuroscience Society Meeting 2011, Auckland New Zealand, 2011.
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Inactivation of sodium current modulates retinal ganglion cell response rate during high frequency stimulation, Neuroscience 2010, San Diego USA, 2010.
  • V Tatarinoff, D Tsai, How Deep is deep Enough? Australian and New Zealand Laboratory Animal Association Conference, 2010 (Best presentation award).
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Retinal ganglion cell responses following subretinal electrical stimulation in the isolated rabbit retina, Neuroscience 2009, Chicago USA, 2009.

Patents

  • D Tsai, J W Morley, G J Suaning, N H Lovell, Stimulation method for maintaining the responsiveness of electrically excitable cells to repeated electrical stimulation. US Patent Office. Patent No. 9,669,213.
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Stimulation method for maintaining the responsiveness of electrically excitable cells to repeated electrical stimulation. Australian Patent Office. Patent No. 2012211030.
  • D Tsai, J W Morley, G J Suaning, N H Lovell, Stimulation method for maintaining the responsiveness of electrically excitable cells to repeated electrical stimulation. European. Pub No: WO/2012/100290.
  • K Shepard, D Tsai, H Kang, J Thimot, Flexible complementary metal-oxide-semiconductor probes for chronic, large-scale neural stimulation and recording, US Patent Office, Provisional Application 62/210,532.
  • D Tsai, Jonathan Terry, K Shepard, Fully implanted, wireless, flexible CMOS surface recording device for the brain, US Patent Office, Provisional Application.
  • D Tsai, K Shepard, Systems and methods for dense, high-channel-count, multichannel data acquisition, US Patent Office, Provisional Application.