CMOS fluorescence-based active microarrays

This project is a multidisciplinary effort to novelly exploit CMOS silicon microelectronics in the design of low-cost, portable, self-contained "gene chip" technology for nucleic acid measurement and detection. Much of this effort is focussed on developing active substrates based on fluorescence detection. One such active microarray is shown below, capable of time-resolved fluorescence detection for background rejection (though time-gating) and fluorescence-lifetime measurement. DNA probe is attached directly to the chip surface for detection.

Related Publications:

• T.-C. Huang, S. Sorgenfrei, K. L. Shepard, P. Gong, and R. Levicky, "A CMOS array sensor for sub-800-ps time-resolved fluorescence detection," IEEE Custom Integrated Circuits Conference, 2007 (to appear)
• D. E. Schwartz, E. Charbon, and K. L. Shepard, "A single-photon avalanche diode imager for fluorescence lifetime applications," Symposium on VLSI Circuits, 2007, pp. 144-245.
• G. Patounakis, K. L. Shepard, and R. Levicky, "Active CMOS array sensor for time-resolved fluorescence detection," IEEE Journal of Solid-State Circuits, November, 2006
• G. Patounakis, K. L. Shepard, and R. Levicky, "Active CMOS biochip for time-resolved fluorescence detection," Symposium on VLSI Circuits, 2005.